Back to Search
Start Over
Correlations of Serological Markers with Development of Systemic Involvement in Adult Immunoglobulin A Vasculitis: A Retrospective Study of 259 Patients in Central China.
- Source :
-
Current medical science [Curr Med Sci] 2021 Oct; Vol. 41 (5), pp. 888-893. Date of Electronic Publication: 2021 Sep 20. - Publication Year :
- 2021
-
Abstract
- Objective: Although relatively rare, adult immunoglobulin A vasculitis (IgAV) can lead to severe complications and longer hospitalization, and result in poor prognosis, when compared to childhood IgAV. Hence, early identification and prevention for patients prone to develop systemic involvement are essential. The purpose of this study was to explore the correlations of common serological markers with the development of systemic involvement in adult IgAV.<br />Methods: A retrospective analysis was performed for adult IgAV patients, who were hospitalized in Wuhan Union Hospital between January 2016 and December 2019. A total of 259 patients were enrolled, and the pre-treatment serological markers were comprehensively assessed.<br />Results: In the present study, 49.0% and 33.2% of patients developed renal and gastrointestinal (GI) involvement, respectively. Furthermore, the elevated levels of white blood cells count, D-Dimer (D-D), C-reactive protein (CRP) and neutrophil granulocyte ratio (NE%) >60% were significantly associated with GI involvement in the univariate analysis, while the decrease in high density lipoprotein level, and the elevated D-D and CRP levels were significantly associated with renal involvement (P<0.05). Moreover, a prediction model that combined multiple markers was established by performing a logistic regression analysis, and this presented a more favorable value of prediction than the individual serological markers.<br />Conclusion: The present study suggests that common serological markers have close correlations with systemic involvement in adult IgAV, and that the establishment of a prediction model for systemic involvement may be helpful in facilitating personalized therapeutic strategies and clinical management for IgAV patients.<br /> (© 2021. Huazhong University of Science and Technology.)
- Subjects :
- Adult
China
Female
Fibrin Fibrinogen Degradation Products metabolism
Gastrointestinal Diseases blood
Hospitalization
Humans
IgA Vasculitis complications
Kidney Diseases blood
Leukocyte Count
Lipoproteins, HDL blood
Male
Middle Aged
Receptors, Immunologic blood
Retrospective Studies
Young Adult
Biomarkers blood
Gastrointestinal Diseases etiology
IgA Vasculitis blood
Kidney Diseases etiology
Subjects
Details
- Language :
- English
- ISSN :
- 2523-899X
- Volume :
- 41
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Current medical science
- Publication Type :
- Academic Journal
- Accession number :
- 34542827
- Full Text :
- https://doi.org/10.1007/s11596-021-2440-0