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Variant-specific interventions to slow down replacement and prevent outbreaks.
- Source :
-
Mathematical biosciences [Math Biosci] 2022 Jan; Vol. 343, pp. 108703. Date of Electronic Publication: 2021 Sep 20. - Publication Year :
- 2022
-
Abstract
- Emergency and establishment of variants of concern (VOC) impose significant challenges for the COVID-19 pandemic control specially when a large portion of the population has not been fully vaccinated. Here we develop a mathematical model and utilize this model to examine the impact of non pharmaceutical interventions, including the COVID-test (PCR, antigen and antibody test) and whole genome sequencing (WGS) test capacity and contact tracing and quarantine strength, on the VOC-induced epidemic wave. We point out the undesirable and unexpected effect of lukewarm tracing and quarantine that can potentially increase the VOC-cases at the outbreak peak time, and we demonstrate the significance of strain-specific interventions to either prevent a VOC-induced outbreak, or to mitigate the epidemic wave when this outbreak is unavoidable.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2021. Published by Elsevier Inc.)
Details
- Language :
- English
- ISSN :
- 1879-3134
- Volume :
- 343
- Database :
- MEDLINE
- Journal :
- Mathematical biosciences
- Publication Type :
- Academic Journal
- Accession number :
- 34547362
- Full Text :
- https://doi.org/10.1016/j.mbs.2021.108703