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5-HT2C agonists and antagonists block different components of behavioral responses to potential, distal, and proximal threat in zebrafish.
- Source :
-
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2021 Nov; Vol. 210, pp. 173276. Date of Electronic Publication: 2021 Sep 20. - Publication Year :
- 2021
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Abstract
- Serotonin (5-HT) receptors have been implicated in responses to aversive stimuli in mammals and fish, but its precise role is still unknown. Moreover, since at least seven families of 5-HT receptors exist in vertebrates, the role of specific receptors is still debated. Aversive stimuli can be classified as indicators of proximal, distal, or potential threat, initiating responses that are appropriate for each of these threat levels. Responses to potential threat usually involve cautious exploration and increased alertness, while responses to distal and proximal threat involve a fight-flight-freeze reaction. We exposed adult zebrafish to a conspecific alarm substance (CAS) and observed behavior during (distal threat) and after (potential threat) exposure, and treated with the 5-HT <subscript>2C</subscript> receptor agonists MK-212 or WAY-161503 or with the antagonist RS-102221. The agonists blocked CAS-elicited defensive behavior (distal threat), but not post-exposure increases in defensive behavior (potential threat), suggesting inhibition of responses to distal threat. MK-212 blocked changes in freezing elicited by acute restraint stress, a model of proximal threat, while RS-102221 blocked changes in geotaxis elicited this stressor. We also found that RS-102221, a 5-HT <subscript>2C</subscript> receptor antagonist, produced small effect on behavior during and after exposure to CAS. Preprint: https://www.biorxiv.org/content/10.1101/2020.10.04.324202; Data and scripts: https://github.com/lanec-unifesspa/5-HT-CAS/tree/master/data/5HT2C.<br /> (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Anxiety drug therapy
Anxiety metabolism
Receptor, Serotonin, 5-HT2C metabolism
Receptors, Serotonin metabolism
Serotonin metabolism
Zebrafish
Behavior, Animal drug effects
Escape Reaction drug effects
Fear drug effects
Serotonin 5-HT2 Receptor Agonists pharmacology
Serotonin 5-HT2 Receptor Antagonists pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5177
- Volume :
- 210
- Database :
- MEDLINE
- Journal :
- Pharmacology, biochemistry, and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 34555392
- Full Text :
- https://doi.org/10.1016/j.pbb.2021.173276