Neurodevelopmental malformations of the cerebellum and neocortex in the Shank3 and Cntnap2 mouse models of autism.

Authors :: Otazu GH
Li Y
Lodato Z
Elnasher A
Keever KM
Li Y
Ramos RL
Source :: Neuroscience letters [Neurosci Lett] 2021 Nov 20; Vol. 765, pp. 136257. Date of Electronic Publication: 2021 Sep 20.
Publication Year :: 2021
Abstract: There are many mouse models of autism with broad use in neuroscience research. Genetic background can be a major contributor to the phenotype observed in any mouse model of disease, including genetic models of autism. C57BL/6 mice display spontaneous glio-neuronal heterotopia in the cerebellar vermis and neocortex which may also exist in mouse models of autism created on this background. In the present report, we document the presence of cerebellar and neocortical heterotopia in heterozygous and KO Shank3 and Cntnap2 mice which are due to the C57BL/6 genotype and discuss the role these malformations may play in research using these genetic models of autism.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)

Subjects :: Animals
Cerebellum abnormalities
Cerebellum pathology
Female
Heterozygote
Humans
Male
Malformations of Cortical Development, Group II pathology
Mice
Mice, Inbred C57BL genetics
Mice, Knockout
Neocortex abnormalities
Neocortex pathology
Autistic Disorder genetics
Disease Models, Animal
Malformations of Cortical Development, Group II genetics
Membrane Proteins genetics
Microfilament Proteins genetics
Nerve Tissue Proteins genetics

Full Text Access

Tools