Back to Search
Start Over
A blueprint of the topology and mechanics of the human ovary for next-generation bioengineering and diagnosis.
- Source :
-
Nature communications [Nat Commun] 2021 Sep 23; Vol. 12 (1), pp. 5603. Date of Electronic Publication: 2021 Sep 23. - Publication Year :
- 2021
-
Abstract
- Although the first dissection of the human ovary dates back to the 17 <superscript>th</superscript> century, the biophysical characteristics of the ovarian cell microenvironment are still poorly understood. However, this information is vital to deciphering cellular processes such as proliferation, morphology and differentiation, as well as pathologies like tumor progression, as demonstrated in other biological tissues. Here, we provide the first readout of human ovarian fiber morphology, interstitial and perifollicular fiber orientation, pore geometry, topography and surface roughness, and elastic and viscoelastic properties. By determining differences between healthy prepubertal, reproductive-age, and menopausal ovarian tissue, we unravel and elucidate a unique biophysical phenotype of reproductive-age tissue, bridging biophysics and female fertility. While these data enable to design of more biomimetic scaffolds for the tissue-engineered ovary, our analysis pipeline is applicable for the characterization of other organs in physiological or pathological states to reveal their biophysical markers or design their bioinspired analogs.<br /> (© 2021. The Author(s).)
- Subjects :
- Adult
Age Factors
Aged
Bioengineering
Child
Child, Preschool
Elastic Tissue anatomy & histology
Elastic Tissue metabolism
Elasticity
Extracellular Matrix chemistry
Extracellular Matrix metabolism
Female
Hormones metabolism
Humans
Middle Aged
Ovarian Follicle growth & development
Ovarian Reserve
Ovary cytology
Viscosity
Young Adult
Ovary anatomy & histology
Ovary physiology
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 34556652
- Full Text :
- https://doi.org/10.1038/s41467-021-25934-4