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Ecofriendly preparation of silver nanoparticles-based nanocomposite stabilized by polysaccharides with antibacterial, antifungal and antiviral activities.
- Source :
-
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine [Biometals] 2021 Dec; Vol. 34 (6), pp. 1313-1328. Date of Electronic Publication: 2021 Sep 25. - Publication Year :
- 2021
-
Abstract
- In the present work, sustainable and green method was used to prepare silver nanoparticles (Ag-NPs), followed with incorporation into tertiary nanocomposite consisted of starch, oxidized cellulose and ethyl cellulose. The prepared tertiary silver-nanocomposite (Ag-NC) was fully characterized via instrumental analysis (UV-vis, FT-IR, XRD, SEM, EDX and TEM) and evaluated for antibacterial, antifungal, and antiviral activities. Ag-NC significantly suppressed growth of tested bacterial strains (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis)  as compared with controls. Antifungal activity revealed that the prepared tertiary Ag-NC has a promising antifungal activity towards unicellular (Candida albicans) and multicellular fungi  ( Aspergillus niger, A. terreus, A. flavus and A. fumigatus). In same line, both Ag-NC and free Ag-NPs have shown a dose-dependent reduction in Vero cell line with maximum non-toxic dose at 6.25 and 12.5 μg/mL, respectively. Both Ag-NPs and Ag-NC exhibited antiviral effects against Herpes simplex virus, Adenovirus and Coxsackie B virus in a dose-dependent manner. Combined treatment of Ag-NPs incorporated into tertiary nanocomposite based on starch, oxidized cellulose and ethyl cellulose opens new possibilities to be more efficient nanomaterials for preventing microbial growth. In conclusion, the prepared tertiary Ag-NC has a promising antibacterial, antifungal as well as antiviral activities.<br /> (© 2021. The Author(s), under exclusive licence to Springer Nature B.V.)
- Subjects :
- Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Antifungal Agents chemistry
Antifungal Agents pharmacology
Antiviral Agents pharmacology
Bacillus subtilis metabolism
Microbial Sensitivity Tests
Silver chemistry
Silver pharmacology
Spectroscopy, Fourier Transform Infrared
Metal Nanoparticles chemistry
Nanocomposites chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1572-8773
- Volume :
- 34
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 34564808
- Full Text :
- https://doi.org/10.1007/s10534-021-00344-7