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Genetic Instability Due to Spindle Anomalies Visualized in Mutants of Dictyostelium .
- Source :
-
Cells [Cells] 2021 Aug 29; Vol. 10 (9). Date of Electronic Publication: 2021 Aug 29. - Publication Year :
- 2021
-
Abstract
- Aberrant centrosome activities in mutants of Dictyostelium discoideum result in anomalies of mitotic spindles that affect the reliability of chromosome segregation. Genetic instabilities caused by these deficiencies are tolerated in multinucleate cells, which can be produced by electric-pulse induced cell fusion as a source for aberrations in the mitotic apparatus of the mutant cells. Dual-color fluorescence labeling of the microtubule system and the chromosomes in live cells revealed the variability of spindle arrangements, of centrosome-nuclear interactions, and of chromosome segregation in the atypical mitoses observed.
- Subjects :
- Dictyostelium growth & development
Dictyostelium metabolism
Microtubules genetics
Microtubules metabolism
Spindle Apparatus metabolism
Spindle Apparatus pathology
rac GTP-Binding Proteins genetics
rac GTP-Binding Proteins metabolism
Chromosome Segregation
Dictyostelium genetics
Genomic Instability
Mitosis
Mutation
Spindle Apparatus genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2073-4409
- Volume :
- 10
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Cells
- Publication Type :
- Academic Journal
- Accession number :
- 34571889
- Full Text :
- https://doi.org/10.3390/cells10092240