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A Review on Preparation of Betulinic Acid and Its Biological Activities.

Authors :
Lou H
Li H
Zhang S
Lu H
Chen Q
Source :
Molecules (Basel, Switzerland) [Molecules] 2021 Sep 14; Vol. 26 (18). Date of Electronic Publication: 2021 Sep 14.
Publication Year :
2021

Abstract

Betulinic acid, a pentacyclic triterpene, is distributed in a variety of plants, such as birch, eucalyptus and plane trees. It shows a wide spectrum of biological and pharmacological properties, such as anti-inflammatory, antibacterial, antiviral, antidiabetic, antimalarial, anti-HIV and antitumor effects. Among them, the antitumor activity of betulinic acid has been extensively studied. However, obtaining betulinic acid from natural resources can no longer meet the needs of medicine and nutrition, so methods such as chemical synthesis and microbial biotransformation have also been used to prepare betulinic acid. At the same time, with the development of synthetic biology and genetic engineering, and the elucidation of the biosynthetic pathways of terpenoid, the biosynthesis of betulinic acid has also been extensively researched. This article reviews the preparation of betulinic acid and its pharmacological activities, in order to provide a reference for the research and utilization of betulinic acid.

Details

Language :
English
ISSN :
1420-3049
Volume :
26
Issue :
18
Database :
MEDLINE
Journal :
Molecules (Basel, Switzerland)
Publication Type :
Academic Journal
Accession number :
34577056
Full Text :
https://doi.org/10.3390/molecules26185583