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Identification and Pathogenicity Evaluation of a Novel Reassortant Infectious Bursal Disease Virus (Genotype A2dB3).
- Source :
-
Viruses [Viruses] 2021 Aug 25; Vol. 13 (9). Date of Electronic Publication: 2021 Aug 25. - Publication Year :
- 2021
-
Abstract
- Infectious bursal disease virus (IBDV) is a non-enveloped, bi-segmented double-stranded RNA virus and the causative agent of a poultry immunosuppressive disease known as infectious bursal disease (IBD). The novel variant IBDV (nVarIBDV) recently posed a great threat to the development of the poultry industry. In this study, we identified a novel segment-reassortant IBDV strain, IBDV-JS19-14701 (Genotype A2dB3). Phylogenic analysis showed that Segments A and B of IBDV-JS19-14701 were derived from emerging nVarIBDV (Genotype A2dB1) and long-prevalent HLJ0504-like strains (Genotype A3B3) in China, respectively. The pathogenicity of IBDV-JS19-14701 was further evaluated via animal experiments. IBDV-JS19-14701 exhibited a similar virulence to chickens with the nVarIBDV. The identification of this reassortment event is beneficial for understanding the epidemiology of nVarIBDV and will contribute to the efficient prevention and control of IBD.
- Subjects :
- Animals
Birnaviridae Infections virology
Chickens virology
Infectious bursal disease virus classification
Phylogeny
Poultry Diseases virology
Specific Pathogen-Free Organisms
Virulence genetics
Birnaviridae Infections veterinary
Genome, Viral
Genotype
Infectious bursal disease virus genetics
Infectious bursal disease virus pathogenicity
Reassortant Viruses genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1999-4915
- Volume :
- 13
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Viruses
- Publication Type :
- Academic Journal
- Accession number :
- 34578267
- Full Text :
- https://doi.org/10.3390/v13091682