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A review of the mechanisms of keratinocytes damage caused by Staphylococcus aureus infection in patients with atopic dermatitis.

Authors :
Tian X
Huang Q
Liang J
Wang J
Zhang J
Yang Y
Ye Q
He S
Li J
Wu Z
Liu Y
Source :
Journal of leukocyte biology [J Leukoc Biol] 2021 Dec; Vol. 110 (6), pp. 1163-1169. Date of Electronic Publication: 2021 Sep 29.
Publication Year :
2021

Abstract

The dysregulation of skin microflora in patients with atopic dermatitis (AD) has become a research hotspot in recent years. Metagenomic studies have shown that microbial diversity is decreased, whereas the Staphylococcus aureus infection is increased in AD. Keratinocytes are the primary barrier against the invasion of external pathogenic microorganisms. Staphylococcus aureus infection can abnormally activate innate and adaptive immune responses in keratinocytes, resulting in a vicious cycle between Staphylococcus aureus infection and AD. This article reviews the mechanisms of inflammatory damage of keratinocytes induced by Staphylococcus aureus infection in patients with AD, providing a theoretical basis for the study of new targeted drugs. This review also suggests for the management of Staphylococcus aureus infection in patients with AD.<br /> (©2021 Society for Leukocyte Biology.)

Details

Language :
English
ISSN :
1938-3673
Volume :
110
Issue :
6
Database :
MEDLINE
Journal :
Journal of leukocyte biology
Publication Type :
Academic Journal
Accession number :
34585438
Full Text :
https://doi.org/10.1002/JLB.3MR0921-030RRR