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Involvement of central sensory pathways in subjects with restless legs syndrome: A neurophysiological study.
- Source :
-
Brain research [Brain Res] 2021 Dec 01; Vol. 1772, pp. 147673. Date of Electronic Publication: 2021 Sep 29. - Publication Year :
- 2021
-
Abstract
- In patients with restless legs syndrome (RLS) a motor cortical disinhibition has been reported in transcranial magnetic stimulation (TMS) studies, but the neuronal excitability in other cortical areas has been poorly explored. The aim of this study was the functional evaluation of thalamo-cortical circuits and inhibitory cortical responses in the sensory cortex in RLS. We assessed the high-frequency somatosensory evoked potentials (HF-SEP) in sixteen subjects suffering from RLS of different degrees of severity. In patients with severe or very severe RLS we found a significant desynchronization with amplitude reduction of both pre- and post-synaptic HF-SEP bursts, which suggest an impairment in the thalamo-cortical projections and in the cortical inhibitory interneurons activity, respectively. The assessment of the central sensory pathways by means of HF-SEP may shed light on the pathophysiological mechanisms of RLS.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Aged
Cerebral Cortex physiopathology
Cortical Synchronization
Evoked Potentials, Somatosensory
Female
Humans
Interneurons
Male
Middle Aged
Motor Cortex physiopathology
Thalamus physiopathology
Transcranial Magnetic Stimulation
Afferent Pathways physiopathology
Central Nervous System physiopathology
Restless Legs Syndrome physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-6240
- Volume :
- 1772
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 34597651
- Full Text :
- https://doi.org/10.1016/j.brainres.2021.147673