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Advances, challenges and opportunities of phylogenetic and social network analysis using COVID-19 data.

Authors :
Wang Y
Zhao Y
Pan Q
Source :
Briefings in bioinformatics [Brief Bioinform] 2022 Jan 17; Vol. 23 (1).
Publication Year :
2022

Abstract

Coronavirus disease 2019 (COVID-19) has attracted research interests from all fields. Phylogenetic and social network analyses based on connectivity between either COVID-19 patients or geographic regions and similarity between syndrome coronavirus 2 (SARS-CoV-2) sequences provide unique angles to answer public health and pharmaco-biological questions such as relationships between various SARS-CoV-2 mutants, the transmission pathways in a community and the effectiveness of prevention policies. This paper serves as a systematic review of current phylogenetic and social network analyses with applications in COVID-19 research. Challenges in current phylogenetic network analysis on SARS-CoV-2 such as unreliable inferences, sampling bias and batch effects are discussed as well as potential solutions. Social network analysis combined with epidemiology models helps to identify key transmission characteristics and measure the effectiveness of prevention and control strategies. Finally, future new directions of network analysis motivated by COVID-19 data are summarized.<br /> (© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)

Details

Language :
English
ISSN :
1477-4054
Volume :
23
Issue :
1
Database :
MEDLINE
Journal :
Briefings in bioinformatics
Publication Type :
Academic Journal
Accession number :
34601563
Full Text :
https://doi.org/10.1093/bib/bbab406