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The influence of essential oils from ZhaLi NuSi Prescription on the pharmacokinetics of its non-volatile components in normal rats.
- Source :
-
Biomedical chromatography : BMC [Biomed Chromatogr] 2022 Jan; Vol. 36 (1), pp. e5257. Date of Electronic Publication: 2021 Oct 21. - Publication Year :
- 2022
-
Abstract
- Hui Medicine ZhaLi NuSi Prescription (ZLNS) is described in "Hui Hui Prescription," and it has been used to treat cerebral infarction in Hui Region, China. In this study, a rapid and reliable ultra-performance liquid chromatography coupled with mass spectrometry (UPLC-MS/MS) method was established and applied to simultaneously determine geniposidic acid, oxypaeoniflorin, hydroxysafflor yellow A, caffeic acid, magnoflorine, paeoniflorin, ferulic acid, β-ecdysterone, icariin, rhein, and baohuoside I in rat plasma. The pharmacokinetic parameters of these components and the influence of essential oils (EOs) on them were investigated in normal rats. The results showed that the pharmacokinetic parameters (AUC <subscript>0 - t</subscript> , AUC <subscript>0 - ∞</subscript> , t <subscript>1/2</subscript> , t <subscript>max</subscript> , c <subscript>max</subscript> ) of the aforementioned compounds were significantly changed after co-administering with ZLNS EO. The AUC values of oxypaeoniflorin, paeoniflorin, ferulic acid, and baohuoside I with EOs were decreased significantly. This is the first report for the comparative pharmacokinetic study of ZLNS bioactive components in normal rats, which may provide the basis for drug interaction study in vivo and insight into their clinical applications.<br /> (© 2021 John Wiley & Sons, Ltd.)
- Subjects :
- Animals
Chromatography, High Pressure Liquid methods
Coumaric Acids blood
Coumaric Acids chemistry
Coumaric Acids pharmacokinetics
Glucosides blood
Glucosides chemistry
Glucosides pharmacokinetics
Herb-Drug Interactions
Limit of Detection
Linear Models
Male
Monoterpenes blood
Monoterpenes chemistry
Monoterpenes pharmacokinetics
Rats
Rats, Sprague-Dawley
Reproducibility of Results
Tandem Mass Spectrometry methods
Drugs, Chinese Herbal chemistry
Drugs, Chinese Herbal pharmacokinetics
Oils, Volatile administration & dosage
Oils, Volatile analysis
Oils, Volatile pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1099-0801
- Volume :
- 36
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biomedical chromatography : BMC
- Publication Type :
- Academic Journal
- Accession number :
- 34611921
- Full Text :
- https://doi.org/10.1002/bmc.5257