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A Brønsted acid catalyzed tandem reaction for the diastereoselective synthesis of cyclobuta-fused tetrahydroquinoline carboxylic esters.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2021 Oct 27; Vol. 19 (41), pp. 8912-8916. Date of Electronic Publication: 2021 Oct 27. - Publication Year :
- 2021
-
Abstract
- A novel Brønsted acid catalyzed tandem reaction provides highly functionalized cyclobuta-fused tetrahydroquinoline carboxylic esters from anilines and 2-alkylenecyclobutanones in good to high yield. During the reaction a dynamic diastereoselective cyclization is achieved, resulting in the formation of three contiguous stereocenters with high stereoselectivity.
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 19
- Issue :
- 41
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 34612296
- Full Text :
- https://doi.org/10.1039/d1ob01518d