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Total synthesis of bioactive tetracyclic norditerpene dilactones.

Total synthesis of bioactive tetracyclic norditerpene dilactones.

Authors :
Zhang Y
Li X
Xu T
Source :
Organic & biomolecular chemistry [Org Biomol Chem] 2021 Nov 03; Vol. 19 (42), pp. 9138-9147. Date of Electronic Publication: 2021 Nov 03.
Publication Year :
2021

Abstract

Tetracyclic norditerpene dilactones are an important class of terpenoids that have been isolated from both terrestrial and marine sources, typically from Podocarpus plants and from filamentous fungi. This class of molecules shares a common 6/6/6/5 tetracyclic ring skeleton, which possesses a densely oxygenated carbon framework and contiguous stereocenters. What's more challenging for synthetic chemists are the consecutive sp <superscript>2</superscript> -hybridized carbon centers, which exacerbates the strain/rigidity of the whole molecule. In addition, many of these molecules display promising biological activities, such as antitumor, insecticidal, anti-feedant, allelopathic, and antibiotic activities. The unique structures and interesting biological profiles of norditerpene dilactones have attracted considerable attention from synthetic chemists. Herein we summarize the synthetic efforts with respect to tetranorditerpene dilactones.

Details

Language :
English
ISSN :
1477-0539
Volume :
19
Issue :
42
Database :
MEDLINE
Journal :
Organic & biomolecular chemistry
Publication Type :
Academic Journal
Accession number :
34622268
Full Text :
https://doi.org/10.1039/d1ob01535d