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Effect of chewing betel nut on the gut microbiota of Hainanese.
- Source :
-
PloS one [PLoS One] 2021 Oct 14; Vol. 16 (10), pp. e0258489. Date of Electronic Publication: 2021 Oct 14 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Betel nut chewing (BNC) is prevalent in South Asia and Southeast Asia. BNC can affect host health by modulating the gut microbiota. The aim of this study is to evaluate the effect of BNC on the gut microbiota of the host. Feces samples were obtained from 34 BNC individuals from Ledong and Lingshui, Hainan, China. The microbiota was analyzed by 16S rRNA gene sequencing. BNC decreased the microbial α-diversity. Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria were the predominant phyla, accounting for 99.35% of the BNC group. The Firmicutes-to-Bacteroidetes ratio was significantly increased in the BNC group compared to a control group. The abundances of the families Aerococcaceae, Neisseriaceae, Moraxellaceae, Porphyromonadaceae, and Planococcaceae were decreased in the BNC/BNC&#95;Male/BNC&#95;Female groups compared to the control group, whereas the abundances of Coriobacteriaceae, Streptococcaceae, Micrococcaceae, Xanthomonadaceae, Coxiellaceae, Nocardioidaceae, Rhodobacteraceae, and Succinivibrionaceae were increased. In general, the gut microbiome profiles suggest that BNC may have positive effects, such as an increase in the abundance of beneficial microbes and a reduction in the abundance of disease-related microbes. However, BNC may also produce an increase in the abundance of disease-related microbes. Therefore, extraction of prebiotic components could increase the beneficial value of betel nut.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Adolescent
Adult
Areca metabolism
Bacteria genetics
Bacteria isolation & purification
Bacteroidetes genetics
Bacteroidetes isolation & purification
China
Discriminant Analysis
Feces microbiology
Female
Firmicutes genetics
Firmicutes isolation & purification
Humans
Least-Squares Analysis
Male
Middle Aged
Plant Extracts chemistry
Principal Component Analysis
Proteobacteria genetics
Proteobacteria isolation & purification
RNA, Ribosomal, 16S analysis
RNA, Ribosomal, 16S genetics
RNA, Ribosomal, 16S metabolism
Young Adult
Areca chemistry
Gastrointestinal Microbiome drug effects
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 16
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 34648581
- Full Text :
- https://doi.org/10.1371/journal.pone.0258489