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PARP1 as a prognostic biomarker for human cancers: a meta-analysis.

Authors :
Huang YH
Yin SJ
Gong YY
Li ZR
Yang Q
Fan YX
Zhou T
Meng R
Wang P
He GH
Source :
Biomarkers in medicine [Biomark Med] 2021 Nov; Vol. 15 (16), pp. 1563-1578. Date of Electronic Publication: 2021 Oct 15.
Publication Year :
2021

Abstract

Aim: A comprehensive meta-analysis was carried out to evaluate the association between high PARP1 expression and clinical outcomes in diverse types of cancers. Materials & methods: The electronic databases for all articles about PARP1 expression and cancers were searched. Additionally, bioinformatics analysis was utilized to validate the results of the meta-analysis. Results: Fifty-two studies with a total of 7140 patients were included in the current meta-analysis. High PARP1 expression was found to be significantly associated with poor overall survival and recurrence in various cancers, which were further strengthened and complemented by the results of bioinformatic analysis. Furthermore, increased PAPR1 expression was also related to clinicopathological features. Conclusion: Our findings confirmed that PARP1 might be a promising biomarker for prognosis in human cancers.

Details

Language :
English
ISSN :
1752-0371
Volume :
15
Issue :
16
Database :
MEDLINE
Journal :
Biomarkers in medicine
Publication Type :
Academic Journal
Accession number :
34651514
Full Text :
https://doi.org/10.2217/bmm-2020-0891