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Photo-Driven Delivery of 125 I-Labeled Nanomicelles for Nucleus-Targeted Internal Conversion Electron-Based Cancer Therapy.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Oct 27; Vol. 13 (42), pp. 49671-49681. Date of Electronic Publication: 2021 Oct 15. - Publication Year :
- 2021
-
Abstract
- As a kind of high linear energy transfer (LET) radiation, internal conversion electrons are emitted from some radionuclides, such as <superscript>125</superscript> I, triggering severe DNA damage to tumor cells when transported into the nucleus. Herein, we develop a curcumin-loaded nanomicelle composed of a photosensitizer chlorin e6 (Ce6) and amphiphilic poly(ethylene glycol) (poly(maleic anhydride- alt -1-octadecene)-poly(ethylene glycol) (C <subscript>18</subscript> -PMH-PEG)) to deliver <superscript>125</superscript> I into the nucleus under 660 nm laser irradiation, leading to the optimized imaging-guided internal conversion electron therapy of cancer. Ce6-containing nanomicelles (Ce6-C <subscript>18</subscript> -PEG) self-assemble with nucleus-targeted curcumin (Cur), obtaining Ce6-C <subscript>18</subscript> -PEG/Cur nanoparticles. After labeling Cur with <superscript>125</superscript> I, Ce6-C <subscript>18</subscript> -PEG/Cur enables single-photon emission computed tomography and fluorescence imaging of the tumor, serving as a guide for follow-up laser irradiation. Notably, the 660 nm laser-triggered photodynamic reaction of Ce6 optimizes the delivery of Ce6-C <subscript>18</subscript> -PEG/ <superscript>125</superscript> I-Cur at various stages, including tumor accumulation, cellular uptake, and lysosome escape, causing plenty of <superscript>125</superscript> I-Cur to enter the nucleus. By this strategy, Ce6-C <subscript>18</subscript> -PEG/ <superscript>125</superscript> I-Cur showed optimal antitumor efficacy and high biosafety in mice treated with local 660 nm laser irradiation using efficient energy deposition of internally converted electrons over short distances. Therefore, our work provides a novel strategy to optimize <superscript>125</superscript> I delivery for tumor treatment.
- Subjects :
- Animals
Antineoplastic Agents chemistry
Cell Line, Tumor
Cell Proliferation drug effects
Chlorophyllides chemistry
Female
Iodine Radioisotopes
Lasers
Mammary Neoplasms, Experimental drug therapy
Mammary Neoplasms, Experimental pathology
Materials Testing
Mice
Mice, Inbred BALB C
Micelles
Optical Imaging
Photochemical Processes
Photosensitizing Agents chemistry
Antineoplastic Agents pharmacology
Cell Nucleus drug effects
Chlorophyllides pharmacology
Curcumin chemistry
Electrons
Nanoparticles chemistry
Photosensitizing Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 13
- Issue :
- 42
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 34652897
- Full Text :
- https://doi.org/10.1021/acsami.1c13249