Back to Search
Start Over
The Association Between Single-Nucleotide Polymorphisms of Co-Stimulatory Genes Within Non-HLA Region and the Prognosis of Leukemia Patients With Hematopoietic Stem Cell Transplantation.
- Source :
-
Frontiers in immunology [Front Immunol] 2021 Oct 04; Vol. 12, pp. 730507. Date of Electronic Publication: 2021 Oct 04 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- To avoid graft rejection, the hematopoietic stem cells with matched classical human leukocyte antigen (HLA) alleles are the primary choice for clinical allogeneic transplantation. However, even if the fully HLA-matched hematopoietic stem cells are used for transplantation, some patients still have poor prognosis after hematopoietic stem cell transplantation (HSCT), suggesting that the HLA system was not the only determinant of the outcomes of HSCT. In this study, we investigated whether the single-nucleotide polymorphisms (SNPs) of the co-stimulatory genes within non-HLA regions were related to the outcomes of HSCT. The genomic DNAs of 163 patients who had acute leukemia and received HSCT and their respective donors were collected for analysis. Thirty-four SNPs located in the four co-stimulatory genes including cytotoxic T-lymphocyte associated protein 4 (CTLA4), CD28, tumor necrosis factor ligand superfamily 4 (TNFSF4), and programmed cell death protein 1 (PDCD1) were selected to explore their relationship with the adverse outcomes after transplantation, including mortality, cytomegalovirus infection, graft-versus-host disease, and relapse. Our results revealed that nine SNPs in the CTLA4 gene, five SNPs in the PDCD1 gene, two SNPs in the TNFSF4 gene, and four SNPs in the CD28 gene were significantly associated with the occurrence of adverse outcomes post-HSCT. These SNPs may play important roles in immune response to allografts post-HSCT and can be the targets for developing strategy to identify appropriate donors.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Chen, Chang, Wang, Lin, Hsu, Wang and Tseng.)
- Subjects :
- Adolescent
Adult
Aged
CD28 Antigens immunology
CTLA-4 Antigen immunology
Child
Child, Preschool
Cytomegalovirus Infections genetics
Cytomegalovirus Infections immunology
Donor Selection
Female
Graft vs Host Disease genetics
Graft vs Host Disease immunology
Humans
Infant
Leukemia genetics
Leukemia immunology
Leukemia mortality
Male
Middle Aged
OX40 Ligand immunology
Programmed Cell Death 1 Receptor immunology
Recurrence
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Young Adult
CD28 Antigens genetics
CTLA-4 Antigen genetics
HLA Antigens immunology
Hematopoietic Stem Cell Transplantation adverse effects
Hematopoietic Stem Cell Transplantation mortality
Leukemia surgery
OX40 Ligand genetics
Polymorphism, Single Nucleotide
Programmed Cell Death 1 Receptor genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 34671352
- Full Text :
- https://doi.org/10.3389/fimmu.2021.730507