Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study.

Authors :: Nathan N
Montagne ME
Macchi O
Rosental PA
Chauveau S
Jeny F
Sesé L
Abou Taam R
Brocvielle M
Brouard J
Catinon M
Chapelon-Abric C
Cohen-Aubart F
Delacourt C
Delestrain C
Deschildre A
Dossier A
Epaud R
Haroche J
Houdouin V
Israel-Biet D
Juvin K
Le Jeune S
Lionnet F
Meinzer U
Mittaine M
Nunes H
Mattioni S
Naccache JM
Odièvre MH
Vincent M
Clement A
Valeyre D
Cavalin C
Source :: Thorax [Thorax] 2022 Apr; Vol. 77 (4), pp. 404-407. Date of Electronic Publication: 2021 Oct 21.
Publication Year :: 2022
Abstract: Inorganic antigens may contribute to paediatric sarcoidosis. Thirty-six patients matched with 36 healthy controls as well as a group of 21 sickle-cell disease (SCD) controls answered an environmental questionnaire. Patients' indirect exposure to inorganic particles, through coresidents' occupations, was higher than in healthy and SCD controls (median score: 2.5 (0.5-7) vs 0.5 (0-2), p=0.003 and 1 (0-2), p=0.012, respectively), especially for construction, exposures to metal dust, talc, abrasive reagents and scouring products. Wood or fossil energies heating were also linked to paediatric sarcoidosis. This study supports a link between mineral environmental exposure due to adult coresident occupations and paediatric sarcoidosis.<br />Competing Interests: Competing interests: None declared.<br /> (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)