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Genetic studies of low abundance human plasma proteins. II. Population genetics of coagulation factor XIIIB.

Authors :
Kamboh MI
Ferrell RE
Source :
American journal of human genetics [Am J Hum Genet] 1986 Dec; Vol. 39 (6), pp. 817-25.
Publication Year :
1986

Abstract

Plasma samples from a large number of different ethnic groups, consisting of U.S. whites, U.S. blacks, Eskimos from Kodiak and St. Lawrence Island, Aleuts of the Pribilof Islands, and three Amerindian groups from Canada and Mexico have been analyzed by isoelectric focusing followed by immunoblotting to determine the magnitude of genetic variation at the F XIIIB structural locus. The synthesis of published data and our new data demonstrate remarkable variation in the distribution of the three common alleles at this locus and establishes F XIIIB as an extremely informative marker for population differentiation and evolutionary studies. Genetic distance analysis based on this variation separates Caucasian, black, and Mongoloid populations into three distinct clusters.

Details

Language :
English
ISSN :
0002-9297
Volume :
39
Issue :
6
Database :
MEDLINE
Journal :
American journal of human genetics
Publication Type :
Academic Journal
Accession number :
3467588