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Alterations in blood vessels during gastric injury and protection.
- Source :
-
Scandinavian journal of gastroenterology. Supplement [Scand J Gastroenterol Suppl] 1986; Vol. 125, pp. 92-6. - Publication Year :
- 1986
-
Abstract
- Recent investigations suggest that the mucosal vascular endothelium is not a passive bystander, and that alterations within the blood vessel wall actively participate in the pathogenesis of gastric mucosal injury. We review here our data on rapidly developing vascular injury as detected by monastral blue deposition and increased vascular permeability measured by Evan's blue extravasation in dose- and time-dependent experiments with ethanol, HCl, and NaOH in the rat. In addition, using in vivo microscopy and laser-Doppler velocimetry, we demonstrate circulatory stasis in the superficial capillaries within about 1 min after topical application of damaging agents, and a gradual decrease in blood flow that correlates with the extent of hemorrhagic erosions. Prostaglandins or sulfhydryl agents prevented the circulatory standstill and the development of hemorrhagic mucosal lesions. We conclude that microvascular damage, increased vascular permeability, and capillary stasis precede the development of hemorrhagic mucosal lesions.
- Subjects :
- Animals
Capillary Permeability drug effects
Ethanol pharmacology
Female
Gastric Mucosa drug effects
Gastric Mucosa pathology
Hydrochloric Acid pharmacology
Prostaglandins pharmacology
Rats
Rats, Inbred Strains
Regional Blood Flow drug effects
Sodium Hydroxide pharmacology
Gastric Mucosa blood supply
Subjects
Details
- Language :
- English
- ISSN :
- 0085-5928
- Volume :
- 125
- Database :
- MEDLINE
- Journal :
- Scandinavian journal of gastroenterology. Supplement
- Publication Type :
- Academic Journal
- Accession number :
- 3469744
- Full Text :
- https://doi.org/10.3109/00365528609093823