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Influence of nimodipine combined with ulinastatin on neurological function and inflammatory reaction in patients with cerebral vasospasm after subarachnoid hemorrhage.
- Source :
-
Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2021 Nov; Vol. 210, pp. 106981. Date of Electronic Publication: 2021 Oct 08. - Publication Year :
- 2021
-
Abstract
- Objective: This study aimed to discuss the influence of nimodipine+ulinastatin on the neurological function and inflammatory reaction in patients with cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH).<br />Methods: Overall, 90 patients with CVS after SAH who were admitted to our hospital were enrolled in this study and randomly divided into research and control groups (n = 45 for both groups). On the basis of conventional therapy, patients in the control group were injected with ulinastatin and those in the research group were injected with ulinastatin+nimodipine through an intravenous drip for 7 days with the others the same as those of the control group.<br />Results: Blood flow velocity in all cerebral arteries was lower in the research group than in the control group after treatment (P < 0.05). Calcitonin gene-related peptide and nitric oxide levels were higher in the research group than in the control group after treatment (P < 0.05). Endothelin levels were lower in the research group than in the control group (P < 0.05). The total effective rate was higher in the research group than in the control group (P < 0.05). Glasgow Coma Scale scores were higher in the research group than in the control group (P < 0.05).<br />Conclusion: The drug combination of nimodipine and ulinastatin improved blood flow and neurological function in patients with CVS after SAH and enhanced the therapeutic efficacy; the underlying mechanism may be associated with the regulation of vascular endothelial dilatation function and the inhibition of relevant inflammatory factors' expression.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Blood Flow Velocity drug effects
Cerebral Arteries drug effects
Cerebral Arteries physiopathology
Drug Therapy, Combination
Female
Glycoproteins administration & dosage
Humans
Male
Middle Aged
Nimodipine administration & dosage
Subarachnoid Hemorrhage physiopathology
Treatment Outcome
Trypsin Inhibitors administration & dosage
Vasodilator Agents administration & dosage
Vasospasm, Intracranial etiology
Vasospasm, Intracranial physiopathology
Glycoproteins therapeutic use
Nimodipine therapeutic use
Subarachnoid Hemorrhage complications
Trypsin Inhibitors therapeutic use
Vasodilator Agents therapeutic use
Vasospasm, Intracranial drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1872-6968
- Volume :
- 210
- Database :
- MEDLINE
- Journal :
- Clinical neurology and neurosurgery
- Publication Type :
- Academic Journal
- Accession number :
- 34700272
- Full Text :
- https://doi.org/10.1016/j.clineuro.2021.106981