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COVID-19 in lung transplant recipients: an overview of the Swedish national experience.

Authors :
Magnusson JM
Larsson H
Alsaleh A
Ekelund J
Karason K
Schult A
Friman V
Felldin M
Søfteland JM
Dellgren G
Oltean M
Source :
Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2021 Dec; Vol. 34 (12), pp. 2597-2608. Date of Electronic Publication: 2021 Nov 14.
Publication Year :
2021

Abstract

Although it is known that solid organ transplant recipients fare worse after COVID-19 infection, data on the impact of COVID-19 on clinical outcomes and allograft function in lung transplant (LTx) recipients are limited and based mainly on reports with short follow-up. In this nationwide study, all LTx recipients with COVID-19 diagnosed from 1 February 2020 to 30 April 2021 were included. The patients were followed until 1 August 2021 or death. We analysed demographics, clinical features, therapeutic management and outcomes, including lung function. Forty-seven patients were identified: median age was 59 (10-78) years, 53.1% were male, and median follow-up was 194 (23-509) days. COVID-19 was asymptomatic or mild at presentation in 48.9%. Nine patients (19.1%) were vaccinated pre-COVID infection. Two patients (4.3%) died within 28 days of testing positive, and the overall survival rate was 85.1%. The patients with asymptomatic or mild symptoms had a higher median % expected forced expiratory volume during the first second than the patients with worse symptoms (P = 0.004). LTx recipients develop the entire spectrum of COVID-19, and in addition to previously acknowledged risk factors, lower pre-COVID lung function was associated with more severe disease presentation.<br /> (© 2021 The Authors. Transplant International published by John Wiley & Sons Ltd on behalf of Steunstichting ESOT.)

Details

Language :
English
ISSN :
1432-2277
Volume :
34
Issue :
12
Database :
MEDLINE
Journal :
Transplant international : official journal of the European Society for Organ Transplantation
Publication Type :
Academic Journal
Accession number :
34709680
Full Text :
https://doi.org/10.1111/tri.14148