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Injectable, Intrinsically Antibacterial Conductive Hydrogels with Self-Healing and pH Stimulus Responsiveness for Epidermal Sensors and Wound Healing.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2021 Nov 17; Vol. 13 (45), pp. 53541-53552. Date of Electronic Publication: 2021 Nov 02. - Publication Year :
- 2021
-
Abstract
- Torealize intelligent and personalized medicine, it is a huge challenge to develop a hydrogel dressing that can be used as a sensor to monitor human health in real-time while promoting wound healing. Herein, an injectable, self-healing, and conductive chitosan-based (CPT) hydrogel with pH responsiveness and intrinsic antibacterial properties was fabricated via a Schiff base linkage and a hydrogen bond. Due to the introduction of Schiff base bonds, the injectable CPT hydrogel exhibits various excellent properties, such as pH responsiveness to sol-gel transition, self-healing properties, and broad-spectrum antibacterial properties even without additional antibacterial agents. In vitro experiments verify the excellent biocompatibility of the as-prepared hydrogel. An in vivo experiment in a mouse full-thickness skin-wound model was performed to confirm the outstanding effect on wound healing. Meanwhile, as epidermal sensors, the conductive hydrogel that perceives various human activities in real-time could provide the real-time analysis of the patient's healthcare information. Based on these excellent properties, the CPT hydrogel, as a biological dressing with a sensing function, lays a solid foundation for the further realization of personalized medicine.
- Subjects :
- Animals
Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents chemistry
Cell Line
Cell Survival drug effects
Chitosan chemical synthesis
Chitosan chemistry
Electric Conductivity
Epidermis
Humans
Hydrogels chemical synthesis
Hydrogels chemistry
Hydrogen-Ion Concentration
Mice
Microbial Sensitivity Tests
Molecular Structure
Particle Size
Anti-Bacterial Agents pharmacology
Chitosan pharmacology
Escherichia coli drug effects
Hydrogels pharmacology
Staphylococcus aureus drug effects
Wound Healing drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 13
- Issue :
- 45
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 34726373
- Full Text :
- https://doi.org/10.1021/acsami.1c14216