Back to Search
Start Over
Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 12: Tetracyclines: tetracycline, chlortetracycline, oxytetracycline, and doxycycline .
- Source :
-
EFSA journal. European Food Safety Authority [EFSA J] 2021 Oct 26; Vol. 19 (10), pp. e06864. Date of Electronic Publication: 2021 Oct 26 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- The specific concentrations of tetracycline, chlortetracycline, oxytetracycline and doxycycline in non-target feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. The FARSC for these four tetracyclines was estimated. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/increased yield were reported for tetracycline, chlortetracycline, oxytetracycline, whilst for doxycycline no suitable data for the assessment were available. Uncertainties and data gaps associated with the levels reported were addressed. It was recommended to perform further studies to supply more diverse and complete data related to the requirements for calculation of the FARSC for these antimicrobials.<br /> (© 2021 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.)
Details
- Language :
- English
- ISSN :
- 1831-4732
- Volume :
- 19
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- EFSA journal. European Food Safety Authority
- Publication Type :
- Academic Journal
- Accession number :
- 34729092
- Full Text :
- https://doi.org/10.2903/j.efsa.2021.6864