Donor Unrestricted T Cells: Linking innate and adaptive immunity.

Authors :: Soma S
Lewinsohn DA
Lewinsohn DM
Source :: Vaccine [Vaccine] 2021 Dec 08; Vol. 39 (50), pp. 7295-7299. Date of Electronic Publication: 2021 Nov 02.
Publication Year :: 2021
Abstract: Donor Unrestricted T Cells (DURTs) are characterized by their use of antigen presentation molecules that are often invariant. As these cells recognize diverse mycobacterial antigens, often found in BCG, these cells have the potential to either serve as targets for vaccination, or as a means to enable the induction of traditional T and B cell immunity. Here, we will review specific DURT family members, and their relationship to BCG.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2021. Published by Elsevier Ltd.)