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RIFM fragrance ingredient safety assessment, 6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-propionaldehyde, CAS Registry Number 33885-51-7.
- Source :
-
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2022 Jan 15; Vol. 159 Suppl 1, pp. 112658. Date of Electronic Publication: 2021 Nov 04. - Publication Year :
- 2022
-
Abstract
- No treatment-related effects at the low and mid doses were observed in gestation, viability and lactation indices, duration of gestation, parturition, sex ratio, maternal care, litter size, and early postnatal pup development consisting of mortality, clinical signs, anogenital distance, areola/nipple retention, T4 thyroid hormone levels, or macroscopic examination. However, the number of litters (N = 5) at the high dose was considered too low for toxicological evaluation. Thus, based on insufficient data at 120 mg/kg/day, the NOAEL for this study was considered to be 60 mg/kg/day (RIFM, 2020d).<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)
- Subjects :
- Academies and Institutes standards
Aldehydes analysis
Animals
Dermatitis, Photoallergic
Dermatitis, Phototoxic
Female
Household Products
Humans
Lactation drug effects
Litter Size
Mutagenicity Tests
No-Observed-Adverse-Effect Level
Perfume chemistry
Pregnancy
Registries
Respiratory System drug effects
Risk Assessment
Skin drug effects
Toxicity Tests
Aldehydes adverse effects
Cosmetics chemistry
Environmental Exposure adverse effects
Odorants analysis
Perfume adverse effects
Pregnancy Outcome
Safety
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6351
- Volume :
- 159 Suppl 1
- Database :
- MEDLINE
- Journal :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Publication Type :
- Academic Journal
- Accession number :
- 34742791
- Full Text :
- https://doi.org/10.1016/j.fct.2021.112658