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Targeting the insulin granule for modulation of insulin exocytosis.
- Source :
-
Biochemical pharmacology [Biochem Pharmacol] 2021 Dec; Vol. 194, pp. 114821. Date of Electronic Publication: 2021 Nov 05. - Publication Year :
- 2021
-
Abstract
- The pancreatic β-cells control insulin secretion in the body to regulate glucose homeostasis, and β-cell stress and dysfunction is characteristic of Type 2 Diabetes. Pharmacological targeting of the β-cell to increase insulin secretion is typically utilised, however, extended use of common drugs such as sulfonylureas are known to result in secondary failure. Moreover, there is evidence they may induce β-cell failure in the long term. Within β-cells, insulin secretory granules (ISG) serve as compartments to store, process and traffic insulin for exocytosis. There is now growing evidence that ISG exist in multiple populations, distinct in their protein composition, motility, age, and capacity for secretion. In this review, we discuss the implications of a heterogenous ISG population in β-cells and highlight the need for more understanding into how unique ISG populations may be targeted in anti-diabetic therapies.<br /> (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Diabetes Mellitus, Type 2 metabolism
Exocytosis physiology
Humans
Hypoglycemic Agents metabolism
Insulin metabolism
Insulin Secretion physiology
Insulin-Secreting Cells metabolism
Diabetes Mellitus, Type 2 drug therapy
Drug Delivery Systems methods
Exocytosis drug effects
Hypoglycemic Agents administration & dosage
Insulin Secretion drug effects
Insulin-Secreting Cells drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2968
- Volume :
- 194
- Database :
- MEDLINE
- Journal :
- Biochemical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 34748819
- Full Text :
- https://doi.org/10.1016/j.bcp.2021.114821