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Resveratrol and Colorectal Cancer: A Molecular Approach to Clinical Researches.
- Source :
-
Current topics in medicinal chemistry [Curr Top Med Chem] 2021; Vol. 21 (29), pp. 2634-2646. - Publication Year :
- 2021
-
Abstract
- Phytochemicals are the most valuable and comprehensive structures, which may have a broad range of protective benefits, from reducing inflammation and speeding healing to preventing infection and fighting cancer. Resveratrol (RSV) is a natural phenolic compound from the oligomeric stilbenoids group, which is usually found in daily human diet, such as grape, peanut, berries and grains. It exhibits anti-inflammatory, neuroprotective, antioxidant, and cancer prevention and treatment effects. RSV is thought to have an impressive outcome in colorectal cancer (CRC) treatment through the vital molecules and cancer signaling pathways, including SIRT1, P53, P21, AMPK, ROS, BMP7, COX-2, NO, caspases, Wnt, TNFs, NF-κB, EMT, and pentose phosphate pathway. Therefore, this paper reviews the current researches on the pharmacological effects and pharmacokinetics of resveratrol and its drug delivery system, as well as clinical studies involving CRC.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Subjects :
- Anti-Inflammatory Agents
Antineoplastic Agents
Antioxidants
Colorectal Neoplasms metabolism
Drug Delivery Systems
Humans
Neuroprotective Agents
Signal Transduction drug effects
Colorectal Neoplasms drug therapy
Resveratrol administration & dosage
Resveratrol pharmacokinetics
Resveratrol pharmacology
Resveratrol therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4294
- Volume :
- 21
- Issue :
- 29
- Database :
- MEDLINE
- Journal :
- Current topics in medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 34749615
- Full Text :
- https://doi.org/10.2174/1568026621666211105093658