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Delayed immune-related neutropenia with hepatitis by pembrolizumab.
- Source :
-
Immunotherapy [Immunotherapy] 2022 Feb; Vol. 14 (2), pp. 101-105. Date of Electronic Publication: 2021 Nov 11. - Publication Year :
- 2022
-
Abstract
- Case presentation: A 72-year-old man with non-small-cell lung cancer received four cycles of pembrolizumab-containing chemotherapy. He developed multiple immune-related adverse events (irAEs) and discontinued immune checkpoint inhibitors (ICIs); however, he developed immune-related hepatitis and grade 4 neutropenia at 92 days and 118 days, respectively, from discontinuation. He received G-CSF and methylprednisolone pulse therapy and recovered from neutropenia 12 days later. Discussion & conclusion: ICI-induced neutropenia is a life-threatening condition. The longest recorded onset in one study cohort is 26 days after the final administration of ICIs. This case developed strikingly delayed immune-related neutropenia manifesting as a delayed irAE. Clinicians should pay close attention to delayed immune-related neutropenia as a possible life-threatening irAE after ICI treatment.
- Subjects :
- Aged
Antibodies, Monoclonal, Humanized immunology
Antibodies, Monoclonal, Humanized therapeutic use
Carcinoma, Non-Small-Cell Lung immunology
Granulocyte Colony-Stimulating Factor therapeutic use
Hepatitis drug therapy
Hepatitis immunology
Humans
Immune Checkpoint Inhibitors immunology
Immune Checkpoint Inhibitors therapeutic use
Lung Neoplasms immunology
Male
Methylprednisolone therapeutic use
Neutropenia drug therapy
Neutropenia immunology
Time
Treatment Outcome
Antibodies, Monoclonal, Humanized adverse effects
Carcinoma, Non-Small-Cell Lung drug therapy
Hepatitis etiology
Immune Checkpoint Inhibitors adverse effects
Lung Neoplasms drug therapy
Neutropenia chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1750-7448
- Volume :
- 14
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Immunotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 34758635
- Full Text :
- https://doi.org/10.2217/imt-2021-0131