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Gut microbiota is associated with bone mineral density : an observational and genome-wide environmental interaction analysis in the UK Biobank cohort.
- Source :
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Bone & joint research [Bone Joint Res] 2021 Nov; Vol. 10 (11), pp. 734-741. - Publication Year :
- 2021
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Abstract
- Aims: Despite the interest in the association of gut microbiota with bone health, limited population-based studies of gut microbiota and bone mineral density (BMD) have been made. Our aim is to explore the possible association between gut microbiota and BMD.<br />Methods: A total of 3,321 independent loci of gut microbiota were used to calculate the individual polygenic risk score (PRS) for 114 gut microbiota-related traits. The individual genotype data were obtained from UK Biobank cohort. Linear regressions were then conducted to evaluate the possible association of gut microbiota with L1-L4 BMD (n = 4,070), total BMD (n = 4,056), and femur total BMD (n = 4,054), respectively. PLINK 2.0 was used to detect the single-nucleotide polymorphism (SNP) × gut microbiota interaction effect on the risks of L1-L4 BMD, total BMD, and femur total BMD, respectively.<br />Results: We detected five, three, and seven candidate gut microbiota-related traits for L1-L4 BMD, total BMD, and femur BMD, respectively, such as genus Dialister (p = 0.004) for L1-L4 BMD, and genus Eisenbergiella (p = 0.046) for total BMD. We also detected two common gut microbiota-related traits shared by L1-L4 BMD, total BMD, and femur total BMD, including genus Escherichia Shigella and genus Lactococcus . Interaction analysis of BMD detected several genes that interacted with gut microbiota, such as phospholipase D1 ( PLD1 ) and endomucin ( EMCN ) interacting with genus Dialister in total BMD, and COL12A1 and Discs Large MAGUK Scaffold Protein 2 ( DLG2 ) interacting with genus Lactococcus in femur BMD.<br />Conclusion: Our results suggest associations between gut microbiota and BMD, which will be helpful to further explore the regulation mechanism and intervention gut microbiota of BMD. Cite this article: Bone Joint Res  2021;10(11):734-741.
Details
- Language :
- English
- ISSN :
- 2046-3758
- Volume :
- 10
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Bone & joint research
- Publication Type :
- Academic Journal
- Accession number :
- 34779240
- Full Text :
- https://doi.org/10.1302/2046-3758.1011.BJR-2021-0181.R1