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Taurine protects blood-milk barrier integrity via limiting inflammatory response in Streptococcus uberis infections.
- Source :
-
International immunopharmacology [Int Immunopharmacol] 2021 Dec; Vol. 101 (Pt B), pp. 108371. Date of Electronic Publication: 2021 Nov 15. - Publication Year :
- 2021
-
Abstract
- Streptococcus uberis (S. uberis) is an important causative agent of mastitis, leading to significant economic losses to dairy industry. This research used a mouse mastitis model to investigate the protective effects of taurine on mammary inflammatory response and blood-milk barrier integrity in S. uberis challenge. The results showed that taurine attenuated S. uberis-induced mammary histopathological changes, especially neutrophil infiltration. The S. uberis-induced expression of pro-inflammatory mediators were decreased significantly by taurine. Further, we demonstrated that taurine limited the S. uberis-induced inflammatory responses via inhibiting the activation of NF-κB and MAPK signaling pathways. Inflammation usually disrupts the mammary barrier system. The recovery of claudin-3 and occludin expressions indicated that attenuation of inflammatory response by taurine can protect the integrity of blood-milk barrier in S. uberis infection. Taken together, our results reveal that the development of taurine as an effective prevention and control strategy for S. uberis-induced mastitis.<br /> (Copyright © 2021. Published by Elsevier B.V.)
- Subjects :
- Animals
Female
Mastitis drug therapy
Mastitis microbiology
Mice
Mice, Inbred C57BL
Random Allocation
Specific Pathogen-Free Organisms
Streptococcal Infections microbiology
Inflammation prevention & control
Mastitis veterinary
Milk
Streptococcal Infections drug therapy
Streptococcus
Taurine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1705
- Volume :
- 101
- Issue :
- Pt B
- Database :
- MEDLINE
- Journal :
- International immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 34789427
- Full Text :
- https://doi.org/10.1016/j.intimp.2021.108371