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Arterial and Cardiac Remodeling Associated With Extra Weight Gain in an Isolated Abdominal Obesity Cohort.

Authors :
Mandry D
Girerd N
Lamiral Z
Huttin O
Filippetti L
Micard E
Ncho Mottoh MB
Böhme P
Chemla D
Zannad F
Rossignol P
Marie PY
Source :
Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2021 Nov 05; Vol. 8, pp. 771022. Date of Electronic Publication: 2021 Nov 05 (Print Publication: 2021).
Publication Year :
2021

Abstract

Introduction: This study aims to assess the changes in cardiovascular remodeling attributable to bodyweight gain in a middle-aged abdominal obesity cohort. A remodeling worsening might explain the increase in cardiovascular risk associated with a dynamic of weight gain. Methods: Seventy-five middle-aged subjects (56 ± 5 years, 38 women) with abdominal obesity and no known cardiovascular disease underwent MRI-based examinations at baseline and at a 6.1 ± 1.2-year follow-up to monitor cardiovascular remodeling and hemodynamic variables, most notably the effective arterial elastance (Ea). Ea is a proxy of the arterial load that must be overcome during left ventricular (LV) ejection, with increased EA resulting in concentric LV remodeling. Results: Sixteen obese subjects had significant weight gain (>7%) during follow-up (WG+), whereas the 59 other individuals did not (WG-). WG+ and WG- exhibited significant differences in the baseline to follow-up evolutions of several hemodynamic parameters, notably diastolic and mean blood pressures (for mean blood pressure, WG+: +9.3 ± 10.9 mmHg vs. WG-: +1.7 ± 11.8 mmHg, p = 0.022), heart rate (WG+: +0.6 ± 9.4 min <superscript>-1</superscript> vs. -8.9 ± 11.5 min <superscript>-1</superscript> , p = 0.003), LV concentric remodeling index (WG: +0.08 ± 0.16 g.mL <superscript>-1</superscript> vs. WG-: -0.02 ± 0.13 g.mL <superscript>-1</superscript> , p = 0.018) and Ea (WG+: +0.20 ± 0.28 mL mmHg <superscript>-1</superscript> vs. WG-: +0.01 ± 0.30 mL mmHg <superscript>-1</superscript> , p = 0.021). The evolution of the LV concentric remodeling index and Ea were also strongly correlated in the overall obese population ( p < 0.001, R <superscript>2</superscript> = 0.31). Conclusions: A weight gain dynamic is accompanied by increases in arterial load and load-related concentric LV remodeling in an isolated abdominal obesity cohort. This remodeling could have a significant impact on cardiovascular risk.<br />Competing Interests: NG, ZL, EM, FZ, and PR were employed by company CHRU-Nancy, INSERM, CIC. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Mandry, Girerd, Lamiral, Huttin, Filippetti, Micard, Ncho Mottoh, Böhme, Chemla, Zannad, Rossignol and Marie.)

Details

Language :
English
ISSN :
2297-055X
Volume :
8
Database :
MEDLINE
Journal :
Frontiers in cardiovascular medicine
Publication Type :
Academic Journal
Accession number :
34805324
Full Text :
https://doi.org/10.3389/fcvm.2021.771022