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Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers.
- Source :
-
Biology of sex differences [Biol Sex Differ] 2021 Nov 22; Vol. 12 (1), pp. 63. Date of Electronic Publication: 2021 Nov 22. - Publication Year :
- 2021
-
Abstract
- Background: Several biomarkers have been identified to predict the outcome of COVID-19 severity, but few data are available regarding sex differences in their predictive role. Aim of this study was to identify sex-specific biomarkers of severity and progression of acute respiratory distress syndrome (ARDS) in COVID-19.<br />Methods: Plasma levels of sex hormones (testosterone and 17β-estradiol), sex-hormone dependent circulating molecules (ACE2 and Angiotensin1-7) and other known biomarkers for COVID-19 severity were measured in male and female COVID-19 patients at admission to hospital. The association of plasma biomarker levels with ARDS severity at admission and with the occurrence of respiratory deterioration during hospitalization was analysed in aggregated and sex disaggregated form.<br />Results: Our data show that some biomarkers could be predictive both for males and female patients and others only for one sex. Angiotensin1-7 plasma levels and neutrophil count predicted the outcome of ARDS only in females, whereas testosterone plasma levels and lymphocytes counts only in males.<br />Conclusions: Sex is a biological variable affecting the choice of the correct biomarker that might predict worsening of COVID-19 to severe respiratory failure. The definition of sex specific biomarkers can be useful to alert patients to be safely discharged versus those who need respiratory monitoring.<br /> (© 2021. The Author(s).)
- Subjects :
- Adult
Angiotensin-Converting Enzyme 2 blood
Angiotensins blood
COVID-19 blood
Estradiol blood
Female
Humans
Male
Middle Aged
Respiratory Distress Syndrome blood
Respiratory Insufficiency blood
SARS-CoV-2
Testosterone blood
Biomarkers blood
COVID-19 complications
Hospitalization
Respiratory Distress Syndrome complications
Respiratory Distress Syndrome diagnosis
Respiratory Insufficiency complications
Respiratory Insufficiency diagnosis
Sex Characteristics
Subjects
Details
- Language :
- English
- ISSN :
- 2042-6410
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biology of sex differences
- Publication Type :
- Academic Journal
- Accession number :
- 34809704
- Full Text :
- https://doi.org/10.1186/s13293-021-00407-x