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Association of SGLT2 Inhibitors With Risk of Atrial Fibrillation and Stroke in Patients With and Without Type 2 Diabetes: A Systemic Review and Meta-Analysis of Randomized Controlled Trials.
- Source :
-
Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 2022 Feb 01; Vol. 79 (2), pp. e145-e152. Date of Electronic Publication: 2022 Feb 01. - Publication Year :
- 2022
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Abstract
- Abstract: Sodium-glucose cotransporter 2 (SGLT2) inhibitors have well-documented effects on reducing hospitalization for heart failure and cardiovascular mortality, although the effect on atrial fibrillation (AF) has not been comprehensively investigated. Therefore, we performed a meta-analysis to assess the association between SGLT2 inhibitors and AF risk by systematically searching PubMed, Embase, and ClinicalTrials.gov. Two investigators independently identified randomized controlled trials, which compared SGLT2 inhibitors with control in patients with type 2 diabetes, heart failure, or chronic kidney disease. Primary outcomes were incident AF and stroke. We included 20 randomized trials involving 63,604 patients. The SGLT2 inhibitors used were dapagliflozin (7 studies, 28,834 patients), canagliflozin (7 studies, 17,440 patients), empagliflozin (5 studies, 9082 patients), and ertugliflozin (1 study, 8246 patients). Follow-up ranged from 24 weeks to 202 weeks. SGLT2 inhibitors treatment was associated with a significant attenuation in the risk of incident AF (odds ratio = 0.82; 95% confidence interval, 0.72-0.93; P = 0.002) compared with control. No significant difference in stroke between SGLT2 inhibitors and control groups was found (odds ratio = 0.99; 95% confidence interval, 0.85-1.15; P = 0.908). This present meta-analysis indicates that SGLT2 inhibitors are associated with a lower risk of incident AF and do not significantly affect stroke risk for patients with and without type 2 diabetes.<br />Competing Interests: The authors report no conflicts of interest.<br /> (Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.)
- Subjects :
- Humans
Randomized Controlled Trials as Topic
Atrial Fibrillation diagnosis
Atrial Fibrillation drug therapy
Atrial Fibrillation epidemiology
Diabetes Mellitus, Type 2 diagnosis
Diabetes Mellitus, Type 2 drug therapy
Diabetes Mellitus, Type 2 epidemiology
Heart Failure complications
Sodium-Glucose Transporter 2 Inhibitors adverse effects
Stroke diagnosis
Stroke epidemiology
Stroke prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1533-4023
- Volume :
- 79
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of cardiovascular pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 34813574
- Full Text :
- https://doi.org/10.1097/FJC.0000000000001183