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Simultaneous determination of isoxaflutole and its two metabolites in corn under field conditions by LC-MS/MS.

Authors :
Lan F
Li Q
Sun L
Yu W
Jiang W
Wang Z
Liu C
Source :
Journal of the science of food and agriculture [J Sci Food Agric] 2022 Jun; Vol. 102 (8), pp. 3480-3486. Date of Electronic Publication: 2021 Dec 06.
Publication Year :
2022

Abstract

Objective: An improved QuEChERS method was established and verified for simultaneous determination of isoxaflutole and its metabolites diketonitrile and benzoic acid analogue residues in corn and plants. This method was mainly used to study the digestion rule and final residue level of isoxaflutole and its metabolites in corn and plants. It was hoped that the safe use of isoxaflutole in corn can be achieved eventually.<br />Method: The method was completed by means of ultra-performance liquid chromatography with triple quadrupole mass spectrometry. The extraction of the target substance was through acetonitrile solution containing 1% acetic acid, and the purification was through primary secondary amine, octadecylsilane and graphitized carbon black sorbent.<br />Results: In the method, the quantitative limits and detection limits of the three analytes were 0.005-0.01 and 0.001-0.003 mg kg <superscript>-1</superscript> respectively. The half-life of isoxaflutole in the plants in Shandong and Anhui was 36.4 and 42.1 days respectively, and the digestion dynamics all conformed to the first-order kinetics. The final residues of isoxaflutole in green corn and mature corn were less than 0.02 mg kg <superscript>-1</superscript> of the maximum residue limit set by the Codex Alimentarius Commission.<br />Conclusions: The residual amount of isoxaflutole in corn and plants at harvest time was acceptable when isoxaflutole was applied once at a dose of 121.5 g a.i. ha <superscript>-1</superscript> . © 2021 Society of Chemical Industry.<br /> (© 2021 Society of Chemical Industry.)

Details

Language :
English
ISSN :
1097-0010
Volume :
102
Issue :
8
Database :
MEDLINE
Journal :
Journal of the science of food and agriculture
Publication Type :
Academic Journal
Accession number :
34820836
Full Text :
https://doi.org/10.1002/jsfa.11681