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Diagnostic Accuracy and Validity of Serological and Molecular Tests for Hepatitis B and C.

Authors :
Zangiabadian M
Zamani A
Nasiri MJ
Behzadi E
Fooladi AAI
Source :
Current pharmaceutical biotechnology [Curr Pharm Biotechnol] 2022; Vol. 23 (6), pp. 803-817.
Publication Year :
2022

Abstract

Introduction: Hepatitis B and C viruses are one of the leading causes of health problems in the world and early diagnosis and treatment of them are very important. Thereby, this study aimed to evaluate the validity and reliability of usable diagnostic tests for the detection of hepatitis B and C viruses in the clinical setting and to compare them with each other.<br />Materials and Methods: In this review article, we have searched major online databases, including PubMed and EMBASE. 42 retrieved articles were published between January 2000 and January 2020, which are summarized in this review.<br />Results: Immunoassay approaches are general techniques for the identification of pathogenic agents, among which ELISA is the gold standard for the detection of HBsAg. While serological techniques are not conclusive, molecular assays are really important because of the high sensitivity to detect chronic hepatitis B without HBeAg, in which viral loads are very low. Biosensors have more elevated selectivity and sensitivity and faster responses compared to other methods.<br />Conclusion: This study suggests that all of the molecular, serological, and biotechnological assays have advantages and disadvantages for diagnosing hepatitis B and C viruses which are dependent on the condition, so we should choose one of them in regards to the time, cost, and laboratory equipment along with the clinical symptoms.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Details

Language :
English
ISSN :
1873-4316
Volume :
23
Issue :
6
Database :
MEDLINE
Journal :
Current pharmaceutical biotechnology
Publication Type :
Academic Journal
Accession number :
34825639
Full Text :
https://doi.org/10.2174/1389201022666210719162802