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Poking COVID-19: Insights on Genomic Constraints among Immune-Related Genes between Qatari and Italian Populations.
- Source :
-
Genes [Genes (Basel)] 2021 Nov 22; Vol. 12 (11). Date of Electronic Publication: 2021 Nov 22. - Publication Year :
- 2021
-
Abstract
- Host genomic information, specifically genomic variations, may characterize susceptibility to disease and identify people with a higher risk of harm, leading to better targeting of care and vaccination. Italy was the epicentre for the spread of COVID-19 in Europe, the first country to go into a national lockdown and has one of the highest COVID-19 associated mortality rates. Qatar, on the other hand has a very low mortality rate. In this study, we compared whole-genome sequencing data of 14398 adults and Qatari-national to 925 Italian individuals. We also included in the comparison whole-exome sequence data from 189 Italian laboratory-confirmed COVID-19 cases. We focused our study on a curated list of 3619 candidate genes involved in innate immunity and host-pathogen interaction. Two population-gene metric scores, the Delta Singleton-Cohort variant score (DSC) and Sum Singleton-Cohort variant score (SSC), were applied to estimate the presence of selective constraints in the Qatari population and in the Italian cohorts. Results based on DSC and SSC metrics demonstrated a different selective pressure on three genes (MUC5AC, ABCA7, FLNA) between Qatari and Italian populations. This study highlighted the genetic differences between Qatari and Italian populations and identified a subset of genes involved in innate immunity and host-pathogen interaction.
- Subjects :
- Adult
Alleles
COVID-19 epidemiology
Communicable Disease Control
Disease Susceptibility metabolism
Exome genetics
Female
Gene Frequency genetics
Genetic Predisposition to Disease epidemiology
Genetics, Population
Genomics methods
Humans
Immunity, Innate immunology
Italy epidemiology
Male
Qatar epidemiology
SARS-CoV-2 genetics
SARS-CoV-2 pathogenicity
Exome Sequencing methods
Whole Genome Sequencing methods
COVID-19 genetics
Genetic Predisposition to Disease genetics
Host Microbial Interactions genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2073-4425
- Volume :
- 12
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Genes
- Publication Type :
- Academic Journal
- Accession number :
- 34828448
- Full Text :
- https://doi.org/10.3390/genes12111842