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Use of Slaughterhouses as Sentinel Points for Genomic Surveillance of Foot-and-Mouth Disease Virus in Southern Vietnam.
- Source :
-
Viruses [Viruses] 2021 Nov 02; Vol. 13 (11). Date of Electronic Publication: 2021 Nov 02. - Publication Year :
- 2021
-
Abstract
- The genetic diversity of foot-and-mouth disease virus (FMDV) poses a challenge to the successful control of the disease, and it is important to identify the emergence of different strains in endemic settings. The objective of this study was to evaluate the sampling of clinically healthy livestock at slaughterhouses as a strategy for genomic FMDV surveillance. Serum samples ( n = 11,875) and oropharyngeal fluid (OPF) samples ( n = 5045) were collected from clinically healthy cattle and buffalo on farms in eight provinces in southern and northern Vietnam (2015-2019) to characterize viral diversity. Outbreak sequences were collected between 2009 and 2019. In two slaughterhouses in southern Vietnam, 1200 serum and OPF samples were collected from clinically healthy cattle and buffalo (2017 to 2019) as a pilot study on the use of slaughterhouses as sentinel points in surveillance. FMDV VP1 sequences were analyzed using discriminant principal component analysis and time-scaled phylodynamic trees. Six of seven serotype-O and -A clusters circulating in southern Vietnam between 2017-2019 were detected at least once in slaughterhouses, sometimes pre-dating outbreak sequences associated with the same cluster by 4-6 months. Routine sampling at slaughterhouses may provide a timely and efficient strategy for genomic surveillance to identify circulating and emerging FMDV strains.
- Subjects :
- Animals
Buffaloes
Cattle
Cattle Diseases virology
Disease Outbreaks veterinary
Foot-and-Mouth Disease virology
Livestock
Molecular Epidemiology
Oropharynx virology
Pilot Projects
Serogroup
Vietnam epidemiology
Abattoirs
Cattle Diseases epidemiology
Foot-and-Mouth Disease epidemiology
Foot-and-Mouth Disease Virus genetics
Genomics
Subjects
Details
- Language :
- English
- ISSN :
- 1999-4915
- Volume :
- 13
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Viruses
- Publication Type :
- Academic Journal
- Accession number :
- 34835007
- Full Text :
- https://doi.org/10.3390/v13112203