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ABO and Rhesus Blood Groups in Acute Puumala Hantavirus Infection.
- Source :
-
Viruses [Viruses] 2021 Nov 13; Vol. 13 (11). Date of Electronic Publication: 2021 Nov 13. - Publication Year :
- 2021
-
Abstract
- Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. We aimed to evaluate whether ABO and rhesus blood groups associate with the susceptibility or the severity of PUUV infection. We analyzed blood groups in 289 adult patients treated in Tampere University hospital due to PUUV infection during the years 1982-2017. Patients' blood group distribution was compared to that of healthy, voluntary blood donors living in the Tampere University Hospital responsibility area ( n = 21,833). The severity of PUUV infection, as judged by the severity of acute kidney injury (AKI), thrombocytopenia, inflammation, capillary leakage, and the length of hospital care, was analyzed across the groups. The ABO and rhesus blood group distributions did not differ between the patients and blood donors. Patients with non-O blood groups had lower systolic blood pressure compared to patients with blood group O, but there was no difference in other markers of capillary leakage or in the severity of AKI. Minor deviations in the number of platelets and leukocytes were detected between the O and non-O blood groups. To conclude, patients with blood group O may be less susceptible to hypotension, but otherwise blood groups have no major influences on disease susceptibility or severity during acute PUUV infection.
- Subjects :
- Acute Kidney Injury blood
Adult
Capillary Leak Syndrome blood
Disease Susceptibility
Female
Hemorrhagic Fever with Renal Syndrome diagnosis
Humans
Hypotension blood
Male
Middle Aged
Puumala virus pathogenicity
Severity of Illness Index
ABO Blood-Group System
Hemorrhagic Fever with Renal Syndrome blood
Rh-Hr Blood-Group System
Subjects
Details
- Language :
- English
- ISSN :
- 1999-4915
- Volume :
- 13
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Viruses
- Publication Type :
- Academic Journal
- Accession number :
- 34835077
- Full Text :
- https://doi.org/10.3390/v13112271