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Clinical validation of clinical decision support systems for medication review: A scoping review.

Authors :
Damoiseaux-Volman BA
Medlock S
van der Meulen DM
de Boer J
Romijn JA
van der Velde N
Abu-Hanna A
Source :
British journal of clinical pharmacology [Br J Clin Pharmacol] 2022 May; Vol. 88 (5), pp. 2035-2051. Date of Electronic Publication: 2021 Dec 15.
Publication Year :
2022

Abstract

The aim of this scoping review is to summarize approaches and outcomes of clinical validation studies of clinical decision support systems (CDSSs) to support (part of) a medication review. A literature search was conducted in Embase and Medline. In total, 30 articles validating a CDSS were ultimately included. Most of the studies focused on detection of adverse drug events, potentially inappropriate medications and drug-related problems. We categorized the included articles in three groups: studies subjectively reviewing the clinical relevance of CDSS's output (21/30 studies) resulting in a positive predictive value (PPV) for clinical relevance of 4-80%; studies determining the relationship between alerts and actual events (10/30 studies) resulting in a PPV for actual events of 5-80%; and studies comparing output of CDSSs to chart/medication reviews in the whole study population (10/30 studies) resulting in a sensitivity of 28-85% and specificity of 42-75%. We found heterogeneity in the methods used and in the outcome measures. The validation studies did not report the use of a published CDSS validation strategy. To improve the effectiveness and uptake of CDSSs supporting a medication review, future research would benefit from a more systematic and comprehensive validation strategy.<br /> (© 2021 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.)

Details

Language :
English
ISSN :
1365-2125
Volume :
88
Issue :
5
Database :
MEDLINE
Journal :
British journal of clinical pharmacology
Publication Type :
Academic Journal
Accession number :
34837238
Full Text :
https://doi.org/10.1111/bcp.15160