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Genetic variability of the HPV16 early genes and LCR. Present and future perspectives.

Genetic variability of the HPV16 early genes and LCR. Present and future perspectives.

Authors :
Bletsa G
Zagouri F
Amoutzias GD
Nikolaidis M
Zografos E
Markoulatos P
Tsakogiannis D
Source :
Expert reviews in molecular medicine [Expert Rev Mol Med] 2021 Dec 01; Vol. 23, pp. e19. Date of Electronic Publication: 2021 Dec 01.
Publication Year :
2021

Abstract

Human papillomavirus 16 (HPV16) infection is the aetiologic factor for the development of cervical dysplasia and is regarded as highly carcinogen, because it is implicated in more than 50% of cervical cancer cases, worldwide. The tumourigenic potential of HPV16 has triggered the extensive sequence analysis of viral genome in order to identify nucleotide variations and amino acid substitutions that influence viral oncogenicity and subsequently the initiation and progression of cervical cancer. Nowadays, specific mutations of HPV16 DNA have been associated with an increased risk of high-grade squamous intraepithelial lesions and invasive cervical cancer (ICC) development, including E6: Q14H, H78Y, L83V, Ε7: N29S, S63F, E2: H35Q, P219S, T310K, E5: I65V, whereas highly conserved regions of viral DNA have been extensively characterised. In addition, numerous novel HPV16 mutations are observed among the studied populations from various geographic regions, hence advocating that different HPV16 strains seem to emerge with different tumourigenic capacities. The present review focuses on the variability of the early genes and the long control region, emphasising on the association of specific mutations with the development of severe dysplasia. Finally, it evaluates whether specific regions of HPV16 DNA are able to serve as valuable biomarkers for cervical cancer risk.

Details

Language :
English
ISSN :
1462-3994
Volume :
23
Database :
MEDLINE
Journal :
Expert reviews in molecular medicine
Publication Type :
Academic Journal
Accession number :
34847982
Full Text :
https://doi.org/10.1017/erm.2021.18