Back to Search
Start Over
A Model of Minor Histocompatibility Antigens in Allogeneic Hematopoietic Cell Transplantation.
- Source :
-
Frontiers in immunology [Front Immunol] 2021 Nov 18; Vol. 12, pp. 782152. Date of Electronic Publication: 2021 Nov 18 (Print Publication: 2021). - Publication Year :
- 2021
-
Abstract
- Minor histocompatibility antigens (mHAg) composed of peptides presented by HLA molecules can cause immune responses involved in graft-versus-host disease (GVHD) and graft-versus-leukemia effects after allogeneic hematopoietic cell transplantation (HCT). The current study was designed to identify individual graft-versus-host genomic mismatches associated with altered risks of acute or chronic GVHD or relapse after HCT between HLA-genotypically identical siblings. Our results demonstrate that in allogeneic HCT between a pair of HLA-identical siblings, a mHAg manifests as a set of peptides originating from annotated proteins and non-annotated open reading frames, which i) are encoded by a group of highly associated recipient genomic mismatches, ii) bind to HLA allotypes in the recipient, and iii) evoke a donor immune response. Attribution of the immune response and consequent clinical outcomes to individual peptide components within this set will likely differ from patient to patient according to their HLA types.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2021 Martin, Levine, Storer, Zheng, Jain, Heavner, Norris, Geraghty, Spellman, Sather, Wu and Hansen.)
- Subjects :
- Adolescent
Adult
Aged
Alleles
Child
Child, Preschool
Disease Susceptibility immunology
Female
Genetic Predisposition to Disease
Genetic Variation
Graft vs Host Disease epidemiology
Graft vs Host Disease etiology
HLA Antigens genetics
HLA Antigens immunology
Humans
Incidence
Infant
Infant, Newborn
Linkage Disequilibrium
Male
Middle Aged
Minor Histocompatibility Antigens genetics
Peptides genetics
Peptides immunology
Transplantation, Homologous
Young Adult
Hematopoietic Stem Cell Transplantation adverse effects
Hematopoietic Stem Cell Transplantation methods
Minor Histocompatibility Antigens immunology
Transplantation Immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 34868058
- Full Text :
- https://doi.org/10.3389/fimmu.2021.782152