An automated radiosynthesis of [ 18 F]DPA-714 on a commercially available radiosynthesizer, Elixys Flex/Chem.

Authors :: McCauley KS
Wilde JH
Bufalino SM
Neumann KD
Source :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2022 Feb; Vol. 180, pp. 110032. Date of Electronic Publication: 2021 Nov 18.
Publication Year :: 2022
Abstract: [ <superscript>18</superscript> F]DPA-714 is a radiotracer specific to the translocator protein (TSPO) and is useful for in vivo Positron Emission Tomography imaging studies. In this report, we have developed an automated radiosynthesis of [ <superscript>18</superscript> F]DPA-714 on a commercially-available radiosynthesis platform, which comports with USP <823> guidelines. The wide availability of the radiosynthesis module and ease of dissemination of the production sequence will facilitate preclinical and clinical research of TSPO-related pathology.<br /> (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Language :: English
ISSN :: 1872-9800
Volume :: 180
Database :: MEDLINE
Journal :: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Publication Type :: Academic Journal
Accession number :: 34871885
Full Text :: https://doi.org/10.1016/j.apradiso.2021.110032

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