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Central Sleep Apnea Is Associated with an Abnormal P-Wave Terminal Force in Lead V 1 in Patients with Acute Myocardial Infarction Independent from Ventricular Function.
- Source :
-
Journal of clinical medicine [J Clin Med] 2021 Nov 26; Vol. 10 (23). Date of Electronic Publication: 2021 Nov 26. - Publication Year :
- 2021
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Abstract
- Sleep-disordered breathing (SDB) is highly prevalent in patients with cardiovascular disease. We have recently shown that an elevation of the electrocardiographic (ECG) parameter P wave terminal force in lead V <subscript>1</subscript> (PTFV <subscript>1</subscript> ) is linked to atrial proarrhythmic activity by stimulation of reactive oxygen species (ROS)-dependent pathways. Since SDB leads to increased ROS generation, we aimed to investigate the relationship between SDB-related hypoxia and PTFV <subscript>1</subscript> in patients with first-time acute myocardial infarction (AMI). We examined 56 patients with first-time AMI. PTFV <subscript>1</subscript> was analyzed in 12-lead ECGs and defined as abnormal when ≥4000 µV*ms. Polysomnography (PSG) to assess SDB was performed within 3-5 days after AMI. SDB was defined by an apnea-hypopnea-index (AHI) >15/h. The multivariable regression analysis showed a significant association between SDB-related hypoxia and the magnitude of PTFV <subscript>1</subscript> independent from other relevant clinical co-factors. Interestingly, this association was mainly driven by central but not obstructive apnea events. Additionally, abnormal PTFV <subscript>1</subscript> was associated with SDB severity (as measured by AHI, B 21.495; CI [10.872 to 32.118]; p < 0.001), suggesting that ECG may help identify patients suitable for SDB screening. Hypoxia as a consequence of central sleep apnea may result in atrial electrical remodeling measured by abnormal PTFV <subscript>1</subscript> in patients with first-time AMI independent of ventricular function. The PTFV <subscript>1</subscript> may be used as a clinical marker for increased SDB risk in cardiovascular patients.
Details
- Language :
- English
- ISSN :
- 2077-0383
- Volume :
- 10
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Journal of clinical medicine
- Publication Type :
- Academic Journal
- Accession number :
- 34884253
- Full Text :
- https://doi.org/10.3390/jcm10235555