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Characteristics of patients with axial spondyloarthritis by geographic regions: PROOF multicountry observational study baseline results.

Authors :
Poddubnyy D
Sieper J
Akar S
Muñoz-Fernández S
Haibel H
Hojnik M
Ganz F
Inman RD
Source :
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2022 Aug 03; Vol. 61 (8), pp. 3299-3308.
Publication Year :
2022

Abstract

Objectives: To compare demographic and clinical characteristics of patients with axial SpA (axSpA) across geographic regions.<br />Methods: Patients With Axial Spondyloarthritis: Multicountry Registry of Clinical Characteristics (PROOF) is an observational study that enrolled recently diagnosed (≤1 year) axSpA patients fulfilling the Assessment of SpondyloArthritis international Society classification criteria from rheumatology clinical practices in 29 countries across six geographic regions. Demographics and disease-related parameters were collected. Here we present baseline data for patients who were classified as radiographic axSpA (r-axSpA) or non-radiographic axSpA (nr-axSpA) confirmed by central reading.<br />Results: Of the 2170 patients enrolled, 1553 were classified based on central evaluation of sacroiliac radiographs [r-axSpA: 1023 (66%); nr-axSpA: 530 (34%)]. Patients with nr-axSpA had a significantly higher occurrence of enthesitis (40% vs 33%), psoriasis (10% vs 5%) and IBD (4% vs 2%) vs r-axSpA patients. Significant differences in axSpA characteristics were observed between geographic regions. The highest occurrence of peripheral arthritis (60%), enthesitis (52%) and dactylitis (12%) was in Latin America, and the lowest was in Canada (9%, 9% and 2%, respectively). The occurrence of uveitis and psoriasis was highest in Canada (18% and 14%, respectively) and lowest in China (6% and <1%, respectively). IBD was highest in Arabia (21%), and no cases were observed in China. In multivariable analysis adjusted for factors potentially affecting peripheral and extramusculoskeletal manifestations, geographic regions still exhibited significant differences in frequencies of uveitis (P < 0.01), psoriasis (P < 0.0001) and peripheral arthritis (P < 0.0001).<br />Conclusion: The multinational PROOF study of axSpA patients showed significant regional differences in peripheral and extramusculoskeletal manifestations of SpA, which could be considered in management guidelines and clinical trials.<br /> (© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology.)

Details

Language :
English
ISSN :
1462-0332
Volume :
61
Issue :
8
Database :
MEDLINE
Journal :
Rheumatology (Oxford, England)
Publication Type :
Academic Journal
Accession number :
34897381
Full Text :
https://doi.org/10.1093/rheumatology/keab901