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An epigenetic aging analysis of randomized metformin and weight loss interventions in overweight postmenopausal breast cancer survivors.
- Source :
-
Clinical epigenetics [Clin Epigenetics] 2021 Dec 17; Vol. 13 (1), pp. 224. Date of Electronic Publication: 2021 Dec 17. - Publication Year :
- 2021
-
Abstract
- Metformin and weight loss relationships with epigenetic age measures-biological aging biomarkers-remain understudied. We performed a post-hoc analysis of a randomized controlled trial among overweight/obese breast cancer survivors (N = 192) assigned to metformin, placebo, weight loss with metformin, or weight loss with placebo interventions for 6 months. Epigenetic age was correlated with chronological age (r = 0.20-0.86; P < 0.005). However, no significant epigenetic aging associations were observed by intervention arms. Consistent with published reports in non-cancer patients, 6 months of metformin therapy may be inadequate to observe expected epigenetic age deceleration. Longer duration studies are needed to better characterize these relationships.Trial Registration: Registry Name: ClincialTrials.Gov.Registration Number: NCT01302379.Date of Registration: February 2011.URL: https://clinicaltrials.gov/ct2/show/NCT01302379.<br /> (© 2021. The Author(s).)
- Subjects :
- Aged
Aging physiology
Biomarkers, Tumor analysis
Biomarkers, Tumor genetics
Breast Neoplasms diagnosis
Female
Humans
Metformin administration & dosage
Middle Aged
Overweight epidemiology
Postmenopause
Survivors statistics & numerical data
Weight Reduction Programs methods
Weight Reduction Programs standards
Weight Reduction Programs statistics & numerical data
Aging genetics
Breast Neoplasms physiopathology
Metformin pharmacology
Overweight therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1868-7083
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical epigenetics
- Publication Type :
- Academic Journal
- Accession number :
- 34920739
- Full Text :
- https://doi.org/10.1186/s13148-021-01218-y