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Clinical implications of chemotherapeutic agent organ toxicity on perioperative care.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Feb; Vol. 146, pp. 112503. Date of Electronic Publication: 2021 Dec 15. - Publication Year :
- 2022
-
Abstract
- Cancer is the second most common cause of death in the United States and is a challenging disease to treat. The treatment options for various cancers include but are not limited to surgery, radiation, and chemotherapy. The mechanism behind chemotherapy is intended to promote cellular damage to cells that are proliferating uncontrollably. Unfortunately for the recipients, most chemotherapeutic agents cannot differentiate between malignant cells and healthy cells and tissues. Thus, chemotherapy-induced toxicities are often observed in once-healthy organs. These effects can be acute and self-limiting or chronic, appearing long after chemotherapy is completed. Cancer survivors can then present for non-cancer related surgeries later in life, due to this toxicity. Furthermore, the administration of chemotherapeutic agents can profoundly impact the anesthetic management of patients who are undergoing surgery. This review discusses how chemotherapy-induced organ toxicity can occur in multiple organ systems and what drugs should be avoided if prior toxicity exists in these organ systems.<br /> (Published by Elsevier Masson SAS.)
- Subjects :
- Anesthesia methods
Anesthetics therapeutic use
Antineoplastic Agents therapeutic use
Clinical Protocols
Humans
Multiple Organ Failure prevention & control
Pain, Postoperative drug therapy
Surgical Procedures, Operative methods
Antineoplastic Agents adverse effects
Multiple Organ Failure chemically induced
Multiple Organ Failure pathology
Neoplasms drug therapy
Perioperative Care methods
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 146
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 34922113
- Full Text :
- https://doi.org/10.1016/j.biopha.2021.112503