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First-line noninvasive management of cytomegalovirus primary infection in pregnancy.
- Source :
-
Journal of perinatal medicine [J Perinat Med] 2021 Dec 20; Vol. 50 (3), pp. 270-276. Date of Electronic Publication: 2021 Dec 20 (Print Publication: 2022). - Publication Year :
- 2021
-
Abstract
- Objectives: To introduce a first-line noninvasive antenatal management of maternal cytomegalovirus (CMV) primary infection based on ultrasound (US) and magnetic resonance imaging (MRI). Amniocentesis (AC) is used as a second-line tool in cases of abnormalities compatible with fetal CMV infection on US and/or MRI screening.<br />Methods: Between January 2011 and October 2018, pregnant women referred with a CMV primary infection on antibody screening were followed up by monthly US scans and a brain MRI at approximately 32 weeks. In cases with US and/or MRI abnormalities compatible with congenital CMV infection, AC was performed to confirm the diagnosis.<br />Results: Ninety pregnant women with a primary CMV infection were included (89 singleton and one twin pregnancy). The first-line screening by US and/or MRI was normal for 72 of 91 fetuses (79%). At birth, 19 of these 72 neonates (26%) had a positive urine sample for CMV but were asymptomatic. US and/or MRI abnormalities were identified in 19 fetuses (21%). AC confirmed a fetal CMV infection in 16 fetuses (84%); 12 pregnancies were terminated, and four were continued, with three symptomatic neonates at birth and one poor neurodevelopmental outcome at postnatal follow-up.<br />Conclusions: First-line noninvasive management of maternal CMV primary infection based on serial US scans and brain MRI can be offered to identify fetuses with severe symptomatic congenital CMV infection and reduce the number of ACs without compromising the fetal outcome.<br /> (© 2021 Walter de Gruyter GmbH, Berlin/Boston.)
- Subjects :
- Abortion, Induced
Adult
Amniocentesis
Brain diagnostic imaging
Cytomegalovirus Infections therapy
Female
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical
Magnetic Resonance Imaging
Pregnancy
Pregnancy Complications, Infectious therapy
Ultrasonography, Prenatal
Cytomegalovirus Infections diagnosis
Pregnancy Complications, Infectious diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1619-3997
- Volume :
- 50
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of perinatal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 34923781
- Full Text :
- https://doi.org/10.1515/jpm-2021-0384